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Vitamin B9 (Folate) Essential for red blood cell formation DNA synthesis Supports healthy cell growth and function Symptoms of a deficiency: Fatigue Weakness Shortness of breath Dizziness Pale skin Headaches Vitamin B12 Supports red blood cell formation Supports nerve function Helps with energy production Supports brain function Symptoms of a deficiency: Numbness or tingling in hands and feet Fatigue Weakness Low tolerance to cold Pale skin Mouth ulcers Memory and cognitive issues As you can see, theres a lot of overlap between symptoms of different B vitamin deficiencies

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2022 (Scientific Reports): Combined NNMT inhibition + reduced calorie diet established a distinct microbiome in DIO mice additional mechanism but still mouse-only data